Listed below are all sites and structures currently listed on the Landmarks Register in the Old Town Cape District . A number of local landmarks are also listed on the National Register of Historic Places. For these, the date of National Registration is also noted.

Cape River Heritage Museum, 538 Independence St., built 1909 (Local registration, 4-17-95).

Hunze House, 312 Bellevue, Built 1891 (Local Registration, 7-24-95).

Briney House, 25 N. Fountain, Ca. 1904-1906 (Local Registration,  11-20-95).

The House at 323 Themis St., Built 1821 (Local Registration, 11-20-95) (National Registration, 6-27-97).

Whitelaw House, 423 Themis St. , Built 1890 (Local Registration, 3-18-96).

Huhn-Harrison House, 340 S. Lorimier St. Built 1906 (Local Registration, 3-18-96) (National Registration, 06-27-02)

D. A. Glenn House, 325 S. Spanish St. , Built 1883 (National Registration, 10-11-79) (Local Registration, 2-20-96).

St. Vincent De Paul Catholic Church, 131 S. Main Street , Built 1853 (National Registration, 4-12-82) (Local Registration, 2-20-96).

George Boardman Clark House, 6 South Fountain Street, Built 1882 (National Registration, 7-22-94) (Local Registration, 2-20-96).

Klostermann Block ( Alliance building), 7-15 South Spanish street , Built 1905 (National Registration, 7-22-94) (Local Registration, 2-20-96).

Steinbeck-Brock House, 9 N. Fountain, circa 1842 (Local Registration, 12-21-98).

Freeman House, 24 N. Middle, Built 1911 (Local Registration 1-19-99).

Engelmann, Edward H. House, 504 Bellevue , Built 1894, (Local Registration, 8-19-02)

NATIONAL REGISTER SITES (Not on Local Registry)

Oliver-Leming House, 740 North Street , Built 1898-99, National Registration, 1979.

Frederick W. Pott House, 823 Themis Street , National Registration, 6-25-99.

August and Amalia Shivelbine House, 303 S. Spanish St. , Built ca. 1890, National Registration 6-25-99.

Robert Felix Wichterich House, 300 Good Hope, Built 1906, National Registration 8-12-99.

Marquette Hotel, 338 Broadway, Built 1928, National Registration, April 11, 2002.

H & H Building, (Himmelberger and Harrison Building) 400 Broadway, built 1908, National Registration, July 17, 2003.

B’Nai Israel Synagogue, 126 S. Main Street , National Registration, May 5, 2004.

The Wood Building , 1-3 South Frederick Street and 605-607 Independence Street, National Registration, December 10, 2003.

The Southeast Missourian Building, 301 Broadway, Built 1925, National Registration, 6-1-2005

The Esquire Theater, 824 Broadway, Built 1947, National Registration, 9-15-05

St. Vincent’s College Building, 201 Morgan Oak, Built 1943, National Registration 9-30-05.

William Henry and Lilla Luce Harrison House, 313 Themis, Built 1897, National Registration 12-6-05.

NATIONAL REGISTER DISTRICTS

Cape Girardeau Downtown Historic District , Located on the 100 block of North Main Street and the 100 block of Broadway.

Haarig Commercial District , Located on the 600 block of Good Hope Street and the 300 block of South Sprigg Street .

Broadway and North Fountain Street Historic District , 320, 324, 338, & 400 Broadway, and 221 North Fountain Street

Warehouse Row Historic District , Located at 19 North Water Street

Broadway-Middle Street Historic District -  Located on the 500 block of Broadway and the 100 Block of North Middle Street.